Previous fractures at multiple sites increase the risk for subsequent fractures: The global longitudinal study of osteoporosis in women
Identifieur interne : 005613 ( Main/Exploration ); précédent : 005612; suivant : 005614Previous fractures at multiple sites increase the risk for subsequent fractures: The global longitudinal study of osteoporosis in women
Auteurs : Stephen Gehlbach [États-Unis] ; Kenneth G. Saag [États-Unis] ; Jonathan D. Adachi [Canada] ; Fred H. Hooven [États-Unis] ; Julie Flahive [États-Unis] ; Steven Boonen [Belgique] ; Roland D. Chapurlat [France] ; Juliet E. Compston [Royaume-Uni] ; Cyrus Cooper [Royaume-Uni] ; Adolfo Díez-Perez [Espagne] ; Susan L. Greenspan [États-Unis] ; Andrea Z. Lacroix [États-Unis] ; J Coen Netelenbos [Pays-Bas] ; Johannes Pfeilschifter [Allemagne] ; Maurizio Rossini [Italie] ; Christian Roux [France] ; Philip N. Sambrook [Australie] ; Stuart Silverman [États-Unis] ; Ethel S. Siris [États-Unis] ; Nelson B. Watts [États-Unis] ; Robert Lindsay [États-Unis]Source :
- Journal of Bone and Mineral Research [ 0884-0431 ] ; 2012-03.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Advisory board member, Amgen, Ankle fractures, Better bone health, Bone health, Bone miner, Chilcott, Cohort, Consulting fees, Female, Fracture, Fracture history, Fracture locations, Fracture risk, Fracture sites, Fractures increase, Future fracture, Future fractures, Gamble, Gehlbach, Honorarium, Incident fracture, Incident fractures, Mammalia, Merck, Mineral research, Novartis, Osteoarticular system, Osteoporos, Osteoporosis, Osteoporotic, Other bones, Other sites, Outcomes research, Past year, Pelvis, Postmenopausal women, Predictor, Previous fracture, Previous fractures, Procter, Procter gamble, Research grants, Risk factors, Roche, Servier, Significant interaction, Site, Subsequent fracture, Subsequent fractures, Vertebral fracture, Warner, Warner chilcott.
- Teeft :
- Advisory board member, Amgen, Ankle fractures, Better bone health, Bone health, Bone miner, Chilcott, Cohort, Consulting fees, Fracture, Fracture history, Fracture locations, Fracture risk, Fracture sites, Fractures increase, Future fracture, Future fractures, Gamble, Gehlbach, Honorarium, Incident fracture, Incident fractures, Merck, Mineral research, Novartis, Osteoporos, Osteoporosis, Osteoporotic, Other bones, Other sites, Outcomes research, Past year, Pelvis, Postmenopausal women, Predictor, Previous fracture, Previous fractures, Procter, Procter gamble, Research grants, Risk factors, Roche, Servier, Significant interaction, Subsequent fracture, Subsequent fractures, Vertebral fracture, Warner, Warner chilcott.
Abstract
Previous fractures of the hip, spine, or wrist are well‐recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women aged ≥55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow‐up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or ≥3 fractures, respectively, since age 45 years. During the first 2 years of follow‐up, 3149 women suffered 3683 incident fractures. Compared with women with no previous fractures, women with 1, 2, or ≥3 prior fractures were 1.8‐, 3.0‐, and 4.8‐fold more likely to have any incident fracture; those with ≥3 prior fractures were 9.1‐fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio [HR] = 7.3) and hip (HR = 3.5). Prior rib fractures were associated with a 2.3‐fold risk of subsequent vertebral fracture, and previous upper leg fracture predicted a 2.2‐fold increased risk of hip fracture. Women with a history of ankle fracture were at 1.8‐fold risk of future fracture of a weight‐bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development. © 2012 American Society for Bone and Mineral Research
Url:
- https://api.istex.fr/document/5D539E4E8B378182059518C7D07E647E07B9B99A/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881741
DOI: 10.1002/jbmr.1476
Affiliations:
- Allemagne, Australie, Belgique, Canada, Espagne, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Alabama, Auvergne-Rhône-Alpes, Californie, Communauté de Madrid, Hollande-Septentrionale, Massachusetts, Ohio, Ontario, Pennsylvanie, Rhône-Alpes, Washington (État), État de New York, Île-de-France
- Amsterdam, Hamilton (Ontario), Lyon, Madrid, Paris, Pittsburgh
- Université McMaster, Université de Pittsburgh
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Le document en format XML
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Saag</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D" last="Adachi">Jonathan D. Adachi</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>St. Joseph's Healthcare, McMaster University, Hamilton, ON</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Hooven, Fred H" sort="Hooven, Fred H" uniqKey="Hooven F" first="Fred H" last="Hooven">Fred H. 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Chapurlat</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Division of Rheumatology, INSERM UMR 1033, Université de Lyon, Hospices Civils de Lyon, Hôpital E Herriot, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E" last="Compston">Juliet E. Compston</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge University Hospitals NHS Foundation Trust, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Diez Erez, Adolfo" sort="Diez Erez, Adolfo" uniqKey="Diez Erez A" first="Adolfo" last="Díez-Perez">Adolfo Díez-Perez</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital del Mar‐IMIM‐Autonomous University of Barcelona, Barcelona, Spain, and RETICEF, ISCIII, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L" last="Greenspan">Susan L. Greenspan</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z" last="Lacroix">Andrea Z. Lacroix</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J Coen" last="Netelenbos">J Coen Netelenbos</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio</wicri:regionArea><wicri:noRegion>Valeggio</wicri:noRegion></affiliation></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Paris Descartes University, Cochin Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sambrook, Philip N" sort="Sambrook, Philip N" uniqKey="Sambrook P" first="Philip N" last="Sambrook">Philip N. Sambrook</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney‐Royal North Shore Hospital, St. Leonards, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Rheumatology, Cedars‐Sinai Medical Center, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S" last="Siris">Ethel S. Siris</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Columbia University Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B" last="Watts">Nelson B. Watts</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Bone and Mineral Research</title><title level="j" type="alt">JOURNAL OF BONE AND MINERAL RESEARCH</title><idno type="ISSN">0884-0431</idno><idno type="eISSN">1523-4681</idno><imprint><biblScope unit="vol">27</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="645">645</biblScope><biblScope unit="page" to="653">653</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-03">2012-03</date></imprint><idno type="ISSN">0884-0431</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0884-0431</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Advisory board member</term><term>Amgen</term><term>Ankle fractures</term><term>Better bone health</term><term>Bone health</term><term>Bone miner</term><term>Chilcott</term><term>Cohort</term><term>Consulting fees</term><term>Female</term><term>Fracture</term><term>Fracture history</term><term>Fracture locations</term><term>Fracture risk</term><term>Fracture sites</term><term>Fractures increase</term><term>Future fracture</term><term>Future fractures</term><term>Gamble</term><term>Gehlbach</term><term>Honorarium</term><term>Incident fracture</term><term>Incident fractures</term><term>Mammalia</term><term>Merck</term><term>Mineral research</term><term>Novartis</term><term>Osteoarticular system</term><term>Osteoporos</term><term>Osteoporosis</term><term>Osteoporotic</term><term>Other bones</term><term>Other sites</term><term>Outcomes research</term><term>Past year</term><term>Pelvis</term><term>Postmenopausal women</term><term>Predictor</term><term>Previous fracture</term><term>Previous fractures</term><term>Procter</term><term>Procter gamble</term><term>Research grants</term><term>Risk factors</term><term>Roche</term><term>Servier</term><term>Significant interaction</term><term>Site</term><term>Subsequent fracture</term><term>Subsequent fractures</term><term>Vertebral fracture</term><term>Warner</term><term>Warner chilcott</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Femelle</term><term>Fracture</term><term>Mammalia</term><term>Ostéoporose</term><term>Site</term><term>Système ostéoarticulaire</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Advisory board member</term><term>Amgen</term><term>Ankle fractures</term><term>Better bone health</term><term>Bone health</term><term>Bone miner</term><term>Chilcott</term><term>Cohort</term><term>Consulting fees</term><term>Fracture</term><term>Fracture history</term><term>Fracture locations</term><term>Fracture risk</term><term>Fracture sites</term><term>Fractures increase</term><term>Future fracture</term><term>Future fractures</term><term>Gamble</term><term>Gehlbach</term><term>Honorarium</term><term>Incident fracture</term><term>Incident fractures</term><term>Merck</term><term>Mineral research</term><term>Novartis</term><term>Osteoporos</term><term>Osteoporosis</term><term>Osteoporotic</term><term>Other bones</term><term>Other sites</term><term>Outcomes research</term><term>Past year</term><term>Pelvis</term><term>Postmenopausal women</term><term>Predictor</term><term>Previous fracture</term><term>Previous fractures</term><term>Procter</term><term>Procter gamble</term><term>Research grants</term><term>Risk factors</term><term>Roche</term><term>Servier</term><term>Significant interaction</term><term>Subsequent fracture</term><term>Subsequent fractures</term><term>Vertebral fracture</term><term>Warner</term><term>Warner chilcott</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous fractures of the hip, spine, or wrist are well‐recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women aged ≥55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow‐up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or ≥3 fractures, respectively, since age 45 years. During the first 2 years of follow‐up, 3149 women suffered 3683 incident fractures. Compared with women with no previous fractures, women with 1, 2, or ≥3 prior fractures were 1.8‐, 3.0‐, and 4.8‐fold more likely to have any incident fracture; those with ≥3 prior fractures were 9.1‐fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio [HR] = 7.3) and hip (HR = 3.5). Prior rib fractures were associated with a 2.3‐fold risk of subsequent vertebral fracture, and previous upper leg fracture predicted a 2.2‐fold increased risk of hip fracture. Women with a history of ankle fracture were at 1.8‐fold risk of future fracture of a weight‐bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development. © 2012 American Society for Bone and Mineral Research</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Alabama</li><li>Auvergne-Rhône-Alpes</li><li>Californie</li><li>Communauté de Madrid</li><li>Hollande-Septentrionale</li><li>Massachusetts</li><li>Ohio</li><li>Ontario</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Washington (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Hamilton (Ontario)</li><li>Lyon</li><li>Madrid</li><li>Paris</li><li>Pittsburgh</li></settlement><orgName><li>Université McMaster</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Gehlbach, Stephen" sort="Gehlbach, Stephen" uniqKey="Gehlbach S" first="Stephen" last="Gehlbach">Stephen Gehlbach</name></region><name sortKey="Flahive, Julie" sort="Flahive, Julie" uniqKey="Flahive J" first="Julie" last="Flahive">Julie Flahive</name><name sortKey="Gehlbach, Stephen" sort="Gehlbach, Stephen" uniqKey="Gehlbach S" first="Stephen" last="Gehlbach">Stephen Gehlbach</name><name sortKey="Gehlbach, Stephen" sort="Gehlbach, Stephen" uniqKey="Gehlbach S" first="Stephen" last="Gehlbach">Stephen Gehlbach</name><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L" last="Greenspan">Susan L. Greenspan</name><name sortKey="Hooven, Fred H" sort="Hooven, Fred H" uniqKey="Hooven F" first="Fred H" last="Hooven">Fred H. Hooven</name><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z" last="Lacroix">Andrea Z. Lacroix</name><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G" last="Saag">Kenneth G. Saag</name><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S" last="Siris">Ethel S. Siris</name><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B" last="Watts">Nelson B. Watts</name></country><country name="Canada"><region name="Ontario"><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D" last="Adachi">Jonathan D. Adachi</name></region></country><country name="Belgique"><noRegion><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D" last="Chapurlat">Roland D. Chapurlat</name></region><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E" last="Compston">Juliet E. Compston</name></noRegion><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Diez Erez, Adolfo" sort="Diez Erez, Adolfo" uniqKey="Diez Erez A" first="Adolfo" last="Díez-Perez">Adolfo Díez-Perez</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J Coen" last="Netelenbos">J Coen Netelenbos</name></region></country><country name="Allemagne"><noRegion><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Sambrook, Philip N" sort="Sambrook, Philip N" uniqKey="Sambrook P" first="Philip N" last="Sambrook">Philip N. 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